AI helps provide the most complete map of interactions key to bacterial survival (phys.org)
TLDR; Summary
- Researchers at Autonomous University of Barcelona use AlphaFold2 AI to map bacterial essential interactome
- 1,402 protein-protein interactions predicted, revealing new details and potential antibiotic targets
- Bacteria's survival processes involve essential protein complexes
- AlphaFold2 distinguishes genuine protein interactions from false positives
- AI model shows excellent predictive power in comparison to experimental data
- Discovery of new essential protein complexes in processes like DNA replication and cell division
- Structural details of protein complexes offer insights for antibiotic development